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GB-5001A

Development stage: Unknown
Lead developer: G2GBio
Modality: Nanoparticles → Drug Delivery Systems, Small Molecules
Administration: Subcutaneous, Intramuscular

Overview

GB-5001A is a long-acting injectable (LAI) formulation of donepezil, a reversible acetylcholinesterase inhibitor, developed by G2G Bio for the treatment of Alzheimer's disease. The drug utilizes G2G Bio's proprietary InnoLamp (Innovative Long-Acting MicroParticle) technology to create a sustained-release microsphere formulation. This delivery system is designed to maintain therapeutic plasma concentrations of donepezil for one month following a single administration, aiming to improve medication adherence and minimize the gastrointestinal side effects typically associated with the peak plasma levels of daily oral dosing. GB-5001A is part of a broader program (GB-5001) that has undergone early-stage clinical evaluation to demonstrate bioequivalence and safety compared to oral donepezil.

Other names: Donepezil 1-month sustained releaseDonepezil1-month sustained releaseDonepezil-1-month sustained releaseDonepezil LAI

Targets

Acetylcholinesterase

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