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GBM6-AD
- Development stage
- Unknown
- Lead developer
- University of Minnesota
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intradermal, Subcutaneous
01
Overview
GBM6-AD is an allogeneic tumor lysate vaccine derived from a specific glioblastoma stem cell line (GBM6). It is designed to stimulate a multi-antigenic immune response against glioma-associated antigens. The vaccine is typically administered with adjuvants such as poly-ICLC or imiquimod, or loaded into autologous dendritic cells to enhance immunogenicity. Clinical studies have evaluated its safety and ability to induce tumor-infiltrating CD8+ T-cell responses in patients with low-grade gliomas, recurrent high-grade gliomas, and diffuse midline gliomas. By presenting a broad spectrum of tumor-specific antigens, GBM6-AD aims to overcome the genetic elusiveness and infiltrative nature of malignant brain tumors.
- Other names
- GBM6-AD vaccineGBM-6-AD vaccineGBM 6-AD vaccineallogeneic glioblastoma stem cell line lysate
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