GC002

**GC002** is a novel gold(I) phosphine complex designed as an antitumor agent with potent cytotoxicity against hepatocellular carcinoma (HCC) cells. It outperforms sorafenib and auranofin by inducing irreversible necroptosis through thioredoxin reductase (TrxR) inhibition at the selenocysteine residue, leading to reactive oxygen species (ROS) accumulation, disruption of redox homeostasis, and activation of the RIP1/RIP3/MLKL pathway. In vivo xenograft studies in Huh7 tumor-bearing mice demonstrated significant tumor growth inhibition at 10 mg/kg via intratumoral injection without severe side effects, positioning GC002 as a promising preclinical candidate for HCC therapy developed by academic researchers.[1]