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GC506
- Development stage
- Phase 1
- Lead developer
- Gracell Biotechnologies
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
GC506 is a Claudin 18.2 (CLDN18.2) targeting CAR-T cell therapy developed by Gracell Biotechnologies Inc. It is designed to treat Claudin 18.2 positive tumors. The therapy incorporates Gracell's proprietary SMART CART™ technology, which aims to overcome the immunosuppressive tumor microenvironment (TME). This is achieved by re-engineering the CAR-T cells to block inhibitory transforming growth factor-beta (TGF-β) signals and convert them into stimulatory signals, thereby enhancing CAR-T cell proliferation, persistence, and cytotoxicity against solid tumors.
- Other names
- CLDN18.2 CAR-TCLDN-18.2 CAR-TCLDN 18.2 CAR-TClaudin 18.2-Targeted Chimeric Antigen Receptor T-cellsClaudin18.2-Targeted Chimeric Antigen Receptor T-cellsClaudin-18.2-Targeted Chimeric Antigen Receptor T-cells
02
Targets
Claudin 18.2
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