Gd-DO3A-GAD

Gd-DO3A-GAD is a gadolinium-based, enzyme-responsive magnetic resonance imaging (MRI) contrast agent designed for the non-invasive imaging and quantification of pancreatic beta cell mass and GABAergic neurons. The agent consists of a Gd-DO3A chelate backbone with glutamate moieties attached via a flexible linker. In its inactive state, the glutamate moieties enter the coordination sphere of the Gd(III) ion, restricting water access and limiting relaxivity. Upon decarboxylation of the glutamate moieties by the enzyme glutamic acid decarboxylase (GAD), the hydration sphere of the Gd(III) ion increases, leading to enhanced T1 relaxivity and allowing selective visualization of GAD activity.

Other names

1-[5-[[N,N'-bis-[3,10,17-triaza-4,11,18-trioxo-21-carboxyl-21-aminoeinecosane]]-N-methylaminocarbonyl]pentyl]-1,4,7,10-tetraazacyclododecane-4,7,10-triacetate (3-) gadolinateGd-DO3A-glutamateGd-DO-3A-glutamateGd-DO 3A-glutamate