Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Gd-DOTA-colchicinic acid
- Development stage
- Preclinical
- Lead developer
- Imperial College London
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
**Gd-DOTA-colchicinic acid** is an experimental small-molecule theranostic conjugate comprising a gadolinium(III)-DOTA magnetic-resonance-imaging chelate linked to colchicinic acid, a colchicine derivative. It binds tubulin and destabilizes microtubules, producing cytotoxic and vascular-disrupting effects, while the gadolinium chelate enables T1-weighted MRI contrast enhancement. In ovarian carcinoma cell lines and OVCAR-3 xenografts, the compound produced tubulin-destabilization-associated cellular changes and central tumor necrosis while reducing tumor T1 relaxation time. It has been reported only in preclinical academic research and has no known marketed product or regulatory approval. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21410265/))
- Other names
- Gd-DOTA-colchicinic acidGd.DOTA.Colchicinic acidGd·DOTA·Colchicinic acid
02
Targets
TUBB (Tubulin (alpha and beta subunits))
Beyond the preview
Go deeper on Gd-DOTA-colchicinic acid.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Gd-DOTA-colchicinic acid.