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gD1-306-HD

Development stage: Preclinical
Lead developer: Molecular Express
Modality: Vaccines & Immunotherapeutics
Administration: Subcutaneous

Overview

gD1-306-HD is a preclinical liposomal vaccine candidate developed by Molecular Express for the prevention or treatment of Herpes Simplex Virus Type 2 (HSV-2) infection. Utilizing the company's proprietary VesiVax platform, the vaccine consists of a truncated HSV-2 glycoprotein D (gD) ectodomain antigen (residues 1-306) formulated within a liposomal delivery system that incorporates an adjuvant. The mechanism of action involves the presentation of the gD antigen to the immune system to elicit a robust neutralizing antibody and T-cell response against HSV-2. The VesiVax platform is designed to enhance the delivery of both the antigen and the adjuvant, potentially improving the immunogenicity and protective efficacy of the vaccine compared to traditional formulations.

Brand names: VesiVax HSV-2 Vaccine
Other names: VesiVax HSV-2 Vaccine

Targets

TLR4 (Toll-like receptor 4)NECTIN1 (Poliovirus receptor-related 1)gD (Herpes simplex virus 1 glycoprotein D)TMEFF2

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