GD2-CAR macrophages

GD2-CAR macrophages are an experimental cell-based immunotherapy consisting of macrophages engineered to express a chimeric antigen receptor (CAR) specific for the GD2 (disialoganglioside) antigen. GD2 is a ganglioside highly expressed in solid tumors, particularly neuroblastoma and melanoma. Unlike CAR-T cells, macrophages possess an inherent ability to infiltrate solid tumors and modulate the immunosuppressive tumor microenvironment (TME). These cells are typically generated either by differentiating human pluripotent stem cells (hPSCs) using CRISPR-Cas9 to integrate the CAR construct into the AAVS1 locus or by lentiviral transduction of monocyte/macrophage cell lines. Once engaged with GD2-positive cells, these CAR-macrophages induce tumor cell clearance through antigen-specific phagocytosis and promote a shift in the immune TME from "cold" to "hot" by recruiting other immune cells such as T cells, neutrophils, and endogenous macrophages.

Other names

GD2-CAR-macrophagesGD-2-CAR-macrophagesGD 2-CAR-macrophagesGD2-targeted CAR macrophagesGD-2-targeted CAR macrophagesGD 2-targeted CAR macrophages