GD2-specific CAR T cells with G3BP1 modulation

GD2-specific CAR T cells with G3BP1 modulation are an experimental cell therapy designed to treat solid tumors, including neuroblastoma and glioblastoma. These CAR T cells are engineered to target the disialoganglioside GD2 and are further modified to modulate the expression of G3BP1 (Ras GTPase-activating protein-binding protein 1), a central regulator of stress granule assembly. The rationale behind this approach is that G3BP1 functions as a stress-buffering checkpoint that tunes CAR T cell fate in response to antigenic and metabolic stress. Preclinical studies have demonstrated that overexpressing G3BP1 can enhance CAR T cell-mediated tumor control by managing the stresses that typically lead to T cell exhaustion in hostile tumor microenvironments, while G3BP1 knockdown has been shown to impair CAR T cell responses.

Other names

GD2-CAR T cells with G3BP1 overexpressionGD-2-CAR T cells with G3BP1 overexpressionGD 2-CAR T cells with G3BP1 overexpressionGD2-CAR T cells with G3BP1 knockdownGD-2-CAR T cells with G3BP1 knockdownGD 2-CAR T cells with G3BP1 knockdown