Drug intelligence / Profile preview

GDC-0980 + paclitaxel

Development stage: Unknown
Lead developer: Genentech
Modality: Small Molecules
Administration: Oral (GDC-0980/apitolisib), Intravenous (paclitaxel)

Overview

GDC-0980 + paclitaxel is a combination of **apitolisib (GDC-0980)**, a dual inhibitor of **class I phosphatidylinositol 3-kinases (PI3K)** and **mammalian target of rapamycin (mTOR) kinases**, with **paclitaxel**, a microtubule-stabilizing chemotherapeutic agent. GDC-0980 blocks key intracellular signaling pathways (PI3K/mTOR) involved in cell growth and survival[1][4][5]. Paclitaxel disrupts microtubule dynamics, causing cell cycle arrest and apoptosis. This combination has been investigated for synergistic antitumor activity, primarily in **locally recurrent or metastatic breast cancer** and other solid tumors[3][5].

Other names: apitolisib + paclitaxel

Targets

mTOR (Mammalian target of rapamycin kinase)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)TUBB (Tubulin (alpha and beta subunits))

Beyond the preview

Go deeper on GDC-0980 + paclitaxel.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on GDC-0980 + paclitaxel.

Explore the full profile