Drug intelligence / Profile preview

GDSH

Development stage
Preclinical
Modality
Nanoparticles → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems
01

Overview

GDSH is a non-specific acronym used in biomedical research to describe several distinct experimental drug delivery and biomaterial platforms. One prominent application is a **gelatin/starch hydrogel** used as a multifunctional tissue adhesive for advanced wound healing; this version often incorporates antioxidant and antibacterial agents to promote angiogenesis and collagen deposition while regulating M1 macrophage polarization. A second application is a **glucose-responsive dual-drug-sequential delivery hydrogel** composed of oxidized hyaluronic acid and carboxymethyl chitosan, designed for the treatment of chronic tendinopathy in diabetic patients by providing spatiotemporal control over the release of growth factors. A third application involves a **self-assembled nanostructure** composed of gadolinium ions, sodium dodecyl sulfate (SDS), and HEPES, which serves as a platform for stabilizing and delivering hydrophobic molecules. Additionally, the acronym is used in environmental science to refer to a statistical modeling framework (Geodetector-Stepwise-Hierarchical Bayesian).

Other names
gelatin/starch hydrogelglucose-responsive dual-drug-sequential delivery hydrogelGd3+/SDS/HEPES complex
02

Targets

PI3K (Phosphoinositide-3-kinase regulatory subunit 6)AKT (RAC-alpha serine/threonine-protein kinase)MEKAMPK (Adenosine monophosphate–activated protein kinase)SMAD (SMAD family)

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