GE-2270A

GE-2270A is a thiopeptide antibiotic produced by the bacterium Planobispora rosea. It acts as a potent inhibitor of bacterial protein synthesis by targeting elongation factor Tu (EF-Tu), an essential component in the translation process. Unlike other EF-Tu inhibitors, it has a distinct spectrum of activity, being particularly effective against Gram-positive bacteria and anaerobes. Structurally, it shares similarities with thiazolyl peptides such as micrococcin but functions analogously to kirromycin-like antibiotics and pulvomycin. While not approved for clinical use itself, it serves as a precursor for compounds under clinical investigation for infections like Clostridium difficile and acne[3][4][5][6].

Other names

Antibiotic GE 2270AANTIBIOTIC GE-2270AUNII-JB4J58L2K1UNII-JB-4J58L2K1UNII-JB 4J58L2K1