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GE11-liposomal CD73 siRNA
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
GE11-liposomal CD73 siRNA is an experimental EGFR-targeted nanoparticle formulation designed to silence the expression of CD73 (ecto-5'-nucleotidase) in the tumor microenvironment. The formulation utilizes the GE11 peptide, which binds specifically to the Epidermal Growth Factor Receptor (EGFR), to facilitate targeted delivery of siRNA-loaded nanoliposomes to tumor cells. By knocking down CD73, the drug reduces the conversion of extracellular AMP to immunosuppressive adenosine, thereby enhancing anti-tumor immune responses, increasing CD8+ T-cell activity, and reducing regulatory T-cell (Treg) infiltration. It has been studied primarily in preclinical models of metastatic breast cancer, often in combination with chemotherapy agents like liposomal doxorubicin.
- Other names
- GE11-Lipo CD73 siRNAGE-11-Lipo CD73 siRNAGE 11-Lipo CD73 siRNAEGFR-Targeted liposomal CD73 siRNA
02
Targets
EGFR T790M (Epidermal growth factor receptor T790M mutant)CD73 (Ecto-5'-nucleotidase)
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