GE11 peptide

GE11 peptide is a 12-amino acid synthetic peptide (sequence YHWYGYTPQNVI, molecular weight 1540 g/mol) specifically designed and optimized for its high affinity and selectivity toward the epidermal growth factor receptor (EGFR)[1][7][9]. Unlike endogenous EGF, GE11 binds EGFR without triggering its mitogenic activity, making it a promising targeting ligand for drug delivery systems (DDS) and nanoparticles directed at EGFR-overexpressing cancer cells[1]. GE11 serves primarily as an active targeting agent to enable the selective delivery of chemotherapeutics, imaging agents, or combined therapeutics to cancers such as breast, ovarian, and liver tumors that exhibit elevated EGFR levels[1][2][3][5]. The peptide has been conjugated to various carriers, including liposomes, polymeric nanoparticles, micelles, and nanogels, for delivery of drugs such as doxorubicin, docetaxel, salinomycin, and siRNA, where it increases cellular uptake, therapeutic efficacy, and reduces off-target toxicity[1][2][3][5].

Other names

YHWYGYTPQNVIGE11GE-11GE 11dodecapeptide GE11