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GEC-TGF-β1
- Development stage
- Unknown
- Lead developer
- Kolon TissueGene
- Modality
- Cell Therapies, Gene Therapies
- Administration
- Intraarticular
01
Overview
GEC-TGF-β1 is an **injectable cell therapy** consisting of genetically engineered chondrocytes virally transduced to express transforming growth factor beta 1 (TGF-β1). Developed to treat degenerative joint disease, specifically knee osteoarthritis, GEC-TGF-β1 introduces allogeneic human chondrocytes that secrete TGF-β1 into the joint space. TGF-β1 is a cytokine with anti-inflammatory and tissue regenerative properties. Preclinical and Phase II clinical studies indicate that intra-articular injection of GEC-TGF-β1 improves joint function and reduces pain in patients with osteoarthritis by modulating inflammatory signaling and promoting cartilage repair[2]. The therapy is developed by TissueGene and labeled in trials as TG-C.
- Brand names
- TG-C
- Other names
- injectable genetically engineered chondrocytes virally transduced with TGF-β1
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