gedunin

Gedunin is a naturally occurring pentacyclic triterpenoid and limonoid, mainly isolated from the neem tree (*Azadirachta indica*) and other plant species[2][8]. It has demonstrated **anticancer**, **antimalarial**, **antifungal**, and **antineoplastic** properties[2][3][8]. Gedunin acts as a **heat shock protein 90 (Hsp90) inhibitor**, inducing degradation of Hsp90-dependent client proteins, and inhibits cancer cell proliferation and metastasis[1][3][7]. It does not competitively bind ATP at the Hsp90 binding site, and its α,β-unsaturated ketone moiety is required for antiproliferative activity but does not appear to act as a Michael acceptor[1]. Studies have shown anticancer efficacy in pancreatic cancer, where gedunin blocks the **sonic hedgehog (Shh)/Gli1 signaling pathway**, epithelial-mesenchymal transition (EMT), migration, invasion, and colony formation, resulting in reduced metastasis and tumor growth in xenograft models[3]. Gedunin is under investigation for its potential as a chemotherapeutic and antimalarial agent[2][7][8].

Other names

CHEBI:659542753-30-2