Drug intelligence / Profile preview

gelatin + thrombin

Development stage
Phase 4
Lead developer
Pfizer
Modality
Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Recombinant Proteins and Enzymes, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration
Topical
01

Overview

Gelatin + thrombin is a combination hemostatic agent used primarily for local control of bleeding during surgery or after trauma. Gelatin acts as an absorbable matrix, providing a scaffold for clot formation, while thrombin is an enzyme that converts fibrinogen to fibrin, accelerating the coagulation cascade and promoting rapid clot formation at the site of application. This combination is typically applied topically—gelatin sponges or matrices are soaked with a solution of thrombin and then placed directly onto bleeding surfaces. The synergistic action enhances hemostasis compared to either component alone. It is widely used in surgical settings where conventional methods (such as suturing or cauterization) are insufficient or impractical[2][5][6].

Brand names
FLOSEAL
Other names
明胶 + 凝血酶
02

Targets

F2R (Protease-activated receptor 1)PAR4 (Protease-activated receptor 4)

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