gelofusine + sodium chloride

Gelofusine + sodium chloride is an intravenous solution used as a **colloidal plasma volume substitute**, primarily for the **treatment of relative or absolute hypovolaemia and shock**, and for prophylaxis and treatment of hypotension, especially during surgical procedures or anesthesia[1][2][3][4]. The solution contains **succinylated gelatin (modified fluid gelatin) 40 g/L** combined with **sodium chloride 7 g/L** with sodium (154 mmol/L) and chloride (120 mmol/L) as electrolytes[1][2][3][4]. **Mechanism of action:** Succinylation introduces negative charges into the gelatin molecule, increasing its molecular volume and colloid osmotic pressure, which allows it to expand vascular plasma volume efficiently, restoring blood pressure and tissue perfusion[1][2][3]. Sodium chloride maintains extracellular fluid volume and electrolyte balance. Gelofusine is generally cleared via the urine, and its physiologic effect lasts several hours[1][2][3]. Primary indications include trauma, surgery, burns, extracorporeal circulation (as priming fluid for heart-lung machines), and other acute blood/fluid losses[1][2][3][4][6]. Use is intravenous only and monitoring for fluid overload, electrolyte disturbances, and hypersensitivity reactions—including anaphylaxis or allergic reactions to gelatin—is required[1][2][3][4]. Developed by B. Braun and manufactured by B. Braun and various other manufacturers internationally.

Brand names

Gelofusine Ecobag

Other names

succinylated gelatin + sodium chloridemodified fluid gelatin + sodium chloride