Drug intelligence / Profile preview

gemcitabine (RenovoRx)

Development stage
Unknown
Lead developer
RenovoRx
Modality
Small Molecules
Administration
Intra-arterial
01

Overview

RenovoGem is a drug-device combination therapy developed by RenovoRx, consisting of the chemotherapy agent gemcitabine delivered via the proprietary RenovoCath micro-catheter using Trans-Arterial Micro-Perfusion (TAMP) technology. This approach is designed to provide targeted, high-concentration delivery of gemcitabine directly to the tumor site through the arterial wall, specifically for the treatment of locally advanced pancreatic adenocarcinoma (LAPC). By utilizing intra-arterial delivery, the system aims to maximize local therapeutic effect while minimizing the systemic toxicities typically associated with intravenous administration. The therapy is currently being evaluated in the Phase 3 TIGeR-PaC clinical trial, comparing it to standard-of-care intravenous gemcitabine and nab-paclitaxel.

Brand names
RenovoGem
Other names
intra-arterial gemcitabinegemcitabine (TAMP)gemcitabine-RenovoRx
02

Targets

DNA polymerase familyRNR (Ribonucleotide reductase)DNA

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