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gemcitabine + cisplatin + capecitabine
- Development stage
- Unknown
- Lead developer
- Eli Lilly
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Gemcitabine + cisplatin + capecitabine is a three-drug chemotherapy combination used primarily for treating advanced pancreatic adenocarcinoma and biliary tract cancers. This regimen combines a nucleoside metabolic inhibitor (gemcitabine), a platinum-based DNA crosslinking agent (cisplatin), and an oral fluoropyrimidine prodrug (capecitabine). Clinical trials have shown this combination may offer improved progression-free survival compared to single-agent therapy in advanced pancreatic cancer.
02
Targets
DNA polymerase familyRNR (Ribonucleotide reductase)TS (Thymidylate synthase)DNA
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