gemcitabine + fluorouracil + docetaxel

This is a **combination chemotherapy regimen** composed of three cytotoxic drugs: **gemcitabine**, **fluorouracil (5-fluorouracil, 5FU)**, and **docetaxel**. - **Gemcitabine** is a nucleoside analog (specifically a deoxycytidine analog) that inhibits DNA synthesis by incorporation into DNA, resulting in masked chain termination and apoptosis of rapidly dividing tumor cells. - **Fluorouracil** is a pyrimidine analog antimetabolite; it inhibits thymidylate synthase, interfering with DNA synthesis and function. - **Docetaxel** is a taxane antineoplastic that promotes and stabilizes microtubule assembly, preventing cell division and leading to apoptosis. This combination has been studied primarily in the adjuvant treatment of pancreatic and biliary cancers, especially after surgical resection and in combination with chemoradiation, and its feasibility and tolerability have been demonstrated in phase II studies[1].