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gemcitabine + nab-paclitaxel
- Development stage
- Phase 4
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Gemcitabine + nab-paclitaxel is a combination chemotherapy regimen primarily used for the treatment of advanced or metastatic pancreatic adenocarcinoma. Gemcitabine (Gemzar) is a nucleoside analog that inhibits DNA synthesis, leading to cell death in rapidly dividing cells. Nab-paclitaxel (Abraxane) is a nanoparticle albumin-bound formulation of paclitaxel, which stabilizes microtubules and prevents their disassembly, thereby inhibiting cell division. Nab-paclitaxel exploits albumin-mediated transport mechanisms to enhance drug delivery to tumors. The combination has demonstrated improved overall survival compared to gemcitabine alone in clinical trials for pancreatic cancer. Mechanistically, preclinical studies suggest that nab-paclitaxel may increase intratumoral concentrations of gemcitabine by reducing levels of cytidine deaminase, the enzyme responsible for metabolizing gemcitabine[3][4][6].
- Brand names
- Abraxane (for nab-paclitaxel)Gemzar (for gemcitabine)
- Other names
- gemcitabine and nab-paclitaxelgemcitabine plus nab-paclitaxelGemzar and Abraxane
02
Targets
DNA polymerase familyMicrotubuleTUBB (Tubulin (alpha and beta subunits))
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