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gemcitabine + paclitaxel + sunitinib
- Development stage
- Phase 2
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
A combination therapy consisting of gemcitabine (a nucleoside analog), paclitaxel (a taxane), and sunitinib (a multi-targeted tyrosine kinase inhibitor). This regimen combines conventional chemotherapy with targeted anti-angiogenic therapy. The combination has been investigated in clinical trials for HER2-negative breast cancer and potentially other advanced solid tumors.
02
Targets
CSF1R (Macrophage colony-stimulating factor receptor)DNA polymerase familyFLT3 (Fms related receptor tyrosine kinase 3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)RET (Rearranged during transfection receptor tyrosine kinase)RNR (Ribonucleotide reductase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)TUBB (Tubulin (alpha and beta subunits))
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