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gemcitabine + TheraSphere
- Development stage
- Unknown
- Lead developer
- Boston Scientific
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous, Intra-arterial
01
Overview
A combination therapy consisting of gemcitabine, a nucleoside analog chemotherapeutic agent, and TheraSphere, a yttrium-90 (Y-90) glass microsphere radioembolization treatment. This combination approach aims to provide both systemic chemotherapy via gemcitabine and targeted radiation therapy to liver tumors through TheraSphere. It has been investigated in clinical trials for treating hepatic metastases from pancreatic cancer and intrahepatic cholangiocarcinoma.
- Brand names
- GemzarTheraSphere
- Other names
- Gemcitabine with TheraSphereGemcitabine + Y-90 TheraSphereGemcitabine plus yttrium-90 radioembolization
02
Targets
ENT (Equilibrative nucleoside transporter family)DNA polymerase familyRNR (Ribonucleotide reductase)
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