Drug intelligence / Profile preview

gemcitabine + TheraSphere

Development stage
Unknown
Lead developer
Boston Scientific
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous, Intra-arterial
01

Overview

A combination therapy consisting of gemcitabine, a nucleoside analog chemotherapeutic agent, and TheraSphere, a yttrium-90 (Y-90) glass microsphere radioembolization treatment. This combination approach aims to provide both systemic chemotherapy via gemcitabine and targeted radiation therapy to liver tumors through TheraSphere. It has been investigated in clinical trials for treating hepatic metastases from pancreatic cancer and intrahepatic cholangiocarcinoma.

Brand names
Gemzar
Other names
Gemcitabine with TheraSphereGemcitabine + Y-90 TheraSphereGemcitabine plus yttrium-90 radioembolization
02

Targets

DNA polymerase familyENT (Equilibrative nucleoside transporter family)RNR (Ribonucleotide reductase)

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