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GEN1044
- Development stage
- Phase 2
- Lead developer
- Genmab
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
GEN1044 is a recombinant immunoglobulin G1 (IgG1) bispecific antibody developed using Genmab's DuoBody platform. It targets both the human T-cell surface antigen CD3 and the oncofetal antigen 5T4 (also known as trophoblast glycoprotein or TPBG). By binding to CD3 on T cells and 5T4 on tumor cells simultaneously, it crosslinks these cell types to trigger a cytotoxic T lymphocyte response against 5T4-expressing tumor cells. The expression of 5T4 is associated with increased invasiveness in various cancers. The drug was investigated for its antineoplastic and immunomodulatory activities in solid tumors but development has been discontinued[2][7][9].
- Other names
- anti-CD3/anti-5T4 bispecific antibody GEN1044DuoBody-CD3x5T4DuoBody-CD-3x5T4DuoBody-CD 3x5T4
02
Targets
CD3 (T-cell surface glycoprotein CD3)TPBG (Trophoblast glycoprotein)
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