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GEN1078

Development stage: Discontinued
Lead developer: Genmab
Modality: Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Injection

Overview

GEN1078 is an investigational drug developed by Genmab for the treatment of malignant solid tumors. It is currently being evaluated in early-phase clinical trials (Phase 1/2) to assess its safety, pharmacokinetics, and preliminary efficacy in patients with advanced or metastatic solid cancers. The precise mechanism of action and molecular target of GEN1078 have not been publicly disclosed as of April 2025. The drug is administered via injection and has not received regulatory approval for any indication[1][2][3][5].

Other names: DuoBody-5T4xCD3DuoBody5T4xCD3DuoBody 5T4xCD3

Targets

TPBG (Trophoblast glycoprotein)CD3 (T-cell surface glycoprotein CD3)

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