Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Gene-modified SQ-SHED
- Development stage
- Preclinical
- Lead developer
- S-Quatre
- Modality
- Gene Therapies, Stem Cell Therapies → Cell Therapies
- Administration
- Intratumoral
01
Overview
Gene-modified SQ-SHED is an investigational gene-modified cell therapy being developed by Kidswell Bio (formerly Gene Techno Science) and its subsidiary S-Quatre Corporation for the treatment of glioblastoma. The therapy utilizes Stem cells from Human Exfoliated Deciduous teeth (SHED), which are processed using the proprietary SQ-SHED culture method. These cells are genetically engineered to express a modified thymidine kinase (TK). In a suicide gene therapy approach, the TK-expressing cells are intended to migrate to the tumor site and convert a prodrug (typically ganciclovir) into a cytotoxic metabolite, thereby inducing targeted cell death in the glioblastoma cells. The program is currently in preclinical development in collaboration with Yamaguchi University School of Medicine.
- Other names
- Gene-modified SQ-SHED-GlioblastomaTK-modified SQ-SHEDGlioblastoma program (modified thymidine kinase)
Beyond the preview
Go deeper on Gene-modified SQ-SHED.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Gene-modified SQ-SHED.