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gene transfected pigskin
- Development stage
- Preclinical
- Lead developer
- XenoTherapeutics
- Modality
- Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Implantable Devices → Device-based Delivery → Drug Delivery Systems, Cell Therapies, Gene Therapies, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Topical, Surgical Implantation
01
Overview
Gene transfected pigskin refers to porcine (pig) skin that has been genetically modified by introducing foreign genetic material (DNA or RNA) into the cells of the skin using a process called transfection. This process can be achieved through various methods such as electroporation, lipid-based delivery, or viral vectors. The goal is to alter the protein expression profile of the pigskin, potentially making it more suitable for medical applications such as xenotransplantation (transplanting animal tissue into humans), wound healing, or as a biological dressing. By modifying specific genes in pigskin, researchers aim to reduce immunogenicity (the likelihood of immune rejection), enhance healing properties, or introduce therapeutic proteins directly at wound sites[2][3]. Gene transfected pigskin is an example of combining cell therapy and gene therapy modalities.
- Other names
- gene-transfected porcine skingenetically modified pigskin
02
Targets
SIRPA (Signal-regulatory protein alpha)Anti-Gal (Alpha-gal epitope-specific antibody)Complement (Complement system)
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