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General Anesthesia (University of Saskatchewan protocol)

Development stage
Unknown
Lead developer
University of Saskatchewan
Modality
Small Molecules
Administration
Intravenous, Inhalation, Oral
01

Overview

This refers to a specific general anesthesia regimen evaluated by the University of Saskatchewan in a clinical trial for managing postoperative pain following total abdominal hysterectomy. The protocol involves a multimodal approach including preoperative analgesics (acetaminophen and naproxen), induction with midazolam, fentanyl, propofol, and rocuronium, and maintenance with sevoflurane. Postoperative pain is managed via a morphine patient-controlled analgesia (PCA) pump. This regimen served as the control arm in a study comparing it against a combined spinal and general anesthesia approach to determine if the addition of spinal anesthesia reduces opioid consumption and hospital stay.

Other names
General Anesthesia (control group)General Anesthesia-University of Saskatchewan-postoperative pain
02

Targets

GABAA (Gamma-aminobutyric acid receptor)HTR2B (5-Hydroxytryptamine Receptor 2B)

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