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general anesthesia-Dr. Lutfi Kirdar Kartal Training and Research Hospital
- Development stage
- Phase 4
- Lead developer
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
- Modality
- Small Molecules
- Administration
- Intravenous, Inhalation
01
Overview
"General anesthesia-Dr. Lutfi Kirdar Kartal Training and Research Hospital" refers to a specific anesthetic protocol utilized in clinical research at the Dr. Lutfi Kirdar Kartal Training and Research Hospital, particularly for pediatric patients undergoing craniotomy. This protocol is a multi-drug regimen consisting of intravenous induction agents and inhalational anesthetics. Specifically, it involves the administration of propofol (a sedative-hypnotic), fentanyl (an opioid analgesic), rocuronium (a non-depolarizing neuromuscular blocker), and sevoflurane (an inhalational anesthetic). The combination is designed to provide a balanced state of controlled unconsciousness, analgesia, and muscle relaxation required for invasive neurosurgical procedures. The hospital's study investigated how mechanical ventilation parameters, such as positive end-expiratory pressure (PEEP), interact with this anesthetic state to affect intracranial pressure markers like optic nerve sheath diameter.
- Other names
- General Anesthesia
02
Targets
GABRR (GABA-A receptor subunit rho)MOR (Mu opioid receptor)Nicotinic Acetylcholine ReceptorGABA-B (Gamma-aminobutyric acid receptor type B)NMDAR (Glutamate receptor ionotropic, NMDA)
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