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genetically modified dendritic cells (lentiviral vector system)

Development stage: Preclinical
Lead developer: Republican Research and Practical Center of Transfusion and Medical Biotechnologies
Modality: Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Gene Therapies

Overview

Genetically modified dendritic cells (lentiviral vector system) is a preclinical-stage cell and gene therapy developed by the Republican Research and Practical Center of Transfusion and Medical Biotechnologies. The therapy utilizes a lentiviral vector system to engineer dendritic cells to express CD40 ligand (CD40L), specific cytokines, and antigens. This approach is designed to enhance the antigen-presenting capacity of the dendritic cells and provide necessary co-stimulatory signals to activate a robust adaptive immune response against tumors or viral infections. The program is currently being investigated for its potential in treating various oncological and viral diseases.

Other names: genetically modified dendritic cells (lentiviral vector system)

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