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Drug intelligence / Profile preview
GeneVax HIV vaccine
- Development stage
- Unknown
- Lead developer
- International AIDS Vaccine Initiative
- Modality
- Viral Vector Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intramuscular
01
Overview
The GeneVax HIV vaccine is a prophylactic prime-boost vaccine candidate developed by Auro Vaccines for the prevention of HIV infection. The regimen utilizes a multiantigen DNA vaccine prime (HIV-MAG) encoding six HIV-1 proteins (Env, Gag, Pol, Nef, Tat, and Vif) co-administered with a DNA plasmid encoding human interleukin-12 (IL-12) as a genetic adjuvant. This prime is delivered via intramuscular electroporation using Ichor Medical Systems' TriGrid delivery system. The prime is followed by a boost with a recombinant adenovirus type 35 vector (Ad35-GRIN/ENV). Developed in partnership with the International AIDS Vaccine Initiative (IAVI), the vaccine is designed to elicit broad cell-mediated immunity, specifically CD4+ and CD8+ T cell responses. It has been evaluated in a Phase 1 clinical trial (B004) which demonstrated safety and tolerability.
- Brand names
- GeneVax
- Other names
- GeneVax HIV vaccineIAVI B004 vaccineHIV-MAG pDNA + GeneVax IL-12 / Ad35-GRIN/ENV
02
Targets
CD46 (CD46 Molecule)Nef (HIV-1 Nef)Pol (HIV-1 Pol polyprotein)Tat (HIV-1 Tat)Vif (HIV-1 Vif)IL-12R (Interleukin-12 receptor)Gag (HIV-1 Gag polyprotein)Human immunodeficiency virus type 1 reverse transcriptasegp41 (Human immunodeficiency virus type 1 glycoprotein 41)
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