genistein + polyunsaturated fatty acids + vitamin K1 + vitamin D3

**genistein + polyunsaturated fatty acids + vitamin K1 + vitamin D3** is a combination dietary supplement studied primarily for bone health in postmenopausal women. The blend, referred to as geniVida bone blend (GBB), typically contains synthetic genistein (30 mg/day), vitamin D3 (800 IU/day), vitamin K1 (150 μg/day), and polyunsaturated fatty acids (1 g/day, EPA/DHA ratio ~2/1)[1][3][5]. - **Mechanism of action:** - **Genistein** is a phytoestrogen/isoflavone that acts as a selective estrogen receptor modulator and helps maintain bone mineral density by mild activation of estrogen receptors primarily in bone tissue. - **Polyunsaturated fatty acids (PUFA)**, mainly omega-3 fatty acids (EPA and DHA), are thought to have anti-inflammatory effects and may synergistically contribute to bone health, potentially via modulation of prostaglandin synthesis and inflammation pathways. - **Vitamin D3** enhances calcium absorption and regulates bone homeostasis. - **Vitamin K1** supports gamma-carboxylation of osteocalcin, a process necessary for bone mineralization[1][3][5]. - **Primary indication:** Prevention of osteoporosis and maintenance of bone mineral density in postmenopausal women; secondary indications under investigation may include general bone health and possible vascular/anti-inflammatory benefits. - **Developer:** DSM Nutritional Products[1][3].

Brand names

geniVida

Other names

GBBgeniVida bone blend