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genistein combined polysaccharide
- Development stage
- Phase 3
- Lead developer
- Amino Up
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Genistein Combined Polysaccharide (GCP) is a proprietary botanical extract produced by the fermentation of soy isoflavones with shiitake mushroom (*Lentinula edodes*) mycelia. This unique fermentation process utilizes mushroom-derived enzymes to convert genistin, the glycoside form of genistein found in soy, into its more bioavailable aglycone form, genistein. The resulting mixture also contains mushroom-derived polysaccharides, primarily alpha-glucans. GCP has been primarily investigated for its potential chemopreventive and therapeutic effects in oncology, particularly for prostate cancer. It is hypothesized to inhibit tumor growth and reduce prostate-specific antigen (PSA) levels through multiple mechanisms, including the inhibition of protein-tyrosine kinases, induction of apoptosis, and modulation of the immune system.
- Brand names
- GCP
- Other names
- Genistein Concentrated Polysaccharide
02
Targets
Androgen receptor / filamin A signaling complexTOP2A (DNA topoisomerase II)ESR1 (ERα)ESR2 (ERβ)PRR (Pattern recognition receptors)RTK (Receptor protein-tyrosine kinase)
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