gentamicin c1a

Gentamicin C1a is one of the major components of the gentamicin complex, which is a mixture of aminoglycoside antibiotics produced by *Micromonospora purpurea* and related actinomycetes[1][3]. Gentamicin C1a acts as a broad-spectrum antibiotic effective against both Gram-positive and Gram-negative bacteria, including severe infections caused by *Pseudomonas aeruginosa*[4][8]. Its primary mechanism of action involves binding to the 30S subunit of bacterial ribosomes, specifically at the A-site RNA in helix 44 of 16S rRNA. This binding disrupts protein synthesis by causing misreading of mRNA and inhibiting translocation, leading to mistranslated proteins that aggregate and ultimately result in bacterial cell death[5][6]. Gentamicin C1a can also slow down peptide chain elongation during translation. It is administered parenterally (IM or IV) for serious infections but may cause nephrotoxicity and ototoxicity as adverse effects[8].

Other names

gentamycin c1a