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Gentiana Dihuang Tongbi Soup is a Traditional Chinese Medicine (TCM) herbal decoction developed by the Jiangsu Provincial Hospital of Traditional Chinese Medicine. It is primarily investigated for the treatment of active rheumatoid arthritis (RA), often in combination with conventional disease-modifying antirheumatic drugs (DMARDs) like methotrexate. The formulation is designed to address "Bi" syndrome (pain and obstruction) by utilizing the anti-inflammatory and immunomodulatory properties of its constituent herbs, which typically include *Gentiana scabra* (Longdan) and *Rehmannia glutinosa* (Dihuang). Clinical research focuses on its ability to improve clinical outcomes, reduce inflammatory markers, and modulate metabolic pathways associated with RA.
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