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genz-644470
- Development stage
- Phase 2
- Lead developer
- Sanofi
- Modality
- Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Small Molecules, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Oral
01
Overview
Genz-644470 is a nonabsorbed, structurally optimized phosphate binding polymer developed for the treatment of hyperphosphataemia in patients with chronic kidney disease (CKD) on hemodialysis. It was designed as a new physical form of sevelamer carbonate, featuring large aggregates of smaller particles to enhance selective phosphate binding and deter entry of competing ions. In clinical studies, Genz-644470 demonstrated effective reduction of serum phosphorus levels in hyperphosphatemic CKD patients on hemodialysis and showed higher phosphate-binding capacity than sevelamer carbonate in vitro. However, its development was discontinued after phase II trials due to lack of significant advantages over existing therapies[1][3][6].
- Other names
- advanced phosphate binder
02
Targets
Pi (Inorganic phosphate)
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