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GEO-ZM01
- Development stage
- Preclinical
- Lead developer
- GeoVax Labs
- Modality
- Viral Vector Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
GEO-ZM01 is a recombinant viral vector vaccine candidate developed by GeoVax Labs for the prevention of Zika virus (ZIKV) infection. Utilizing the Modified Vaccinia Ankara (MVA) platform, the vaccine is engineered to express the ZIKV pre-membrane (prM) and envelope (E) proteins. Upon administration, these proteins are produced by host cells and self-assemble into non-infectious virus-like particles (VLPs) that mimic the structure of the native virus. This process triggers a comprehensive immune response, primarily characterized by the production of neutralizing antibodies against the ZIKV envelope protein, which is essential for viral attachment and entry into host cells. GEO-ZM01 is designed to provide protective immunity with a single dose and aims to avoid the risk of antibody-dependent enhancement (ADE), a significant challenge in the development of vaccines for flaviviruses.
- Other names
- ZIKV envelope protein vaccineZika virus envelope protein vaccineGeoVax Zika vaccine
02
Targets
ZIKV E (Zika virus envelope protein)
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