german chamomile extract

German chamomile extract, derived from the flowers of *Matricaria chamomilla*, is a complex botanical preparation utilized for its therapeutic anxiolytic, anti-inflammatory, and spasmolytic effects. Its pharmacodynamic profile is driven by several key bioactive constituents, most notably the flavonoid apigenin and the sesquiterpenes chamazulene and α-bisabolol. Apigenin functions as a ligand for central benzodiazepine receptors, acting as a positive allosteric modulator of the GABA-A receptor to induce mild sedation and reduce anxiety without the significant side effects associated with synthetic benzodiazepines. Additionally, the extract exhibits potent anti-inflammatory properties by inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) pathways, which reduces the synthesis of pro-inflammatory prostaglandins and leukotrienes. It is widely applied in both clinical and traditional settings for the treatment of generalized anxiety disorder, gastrointestinal spasms, and various inflammatory conditions of the skin and mucous membranes.

Brand names

KamillosanChamomilla Curarina

Other names

Matricaria recutita extractMatricaria chamomilla extractWild chamomile extract