GET-73

GET-73 is an investigational small molecule drug structurally related to gamma-hydroxybutyric acid (GHB). It has been developed primarily for the treatment of alcohol use disorder (AUD) and has demonstrated the ability to reduce alcohol intake and exert anxiolytic effects in preclinical models. The compound is believed to act as a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), though its exact mechanism of action remains under investigation. In addition to its anti-alcohol and anxiolytic properties, GET-73 may also have neuroprotective effects, such as improving memory in animal models. Clinical development has included phase I and II studies in individuals with alcohol dependence[1][2][3][4][5].

Other names

4-Methoxy-N-((4-(trifluoromethyl)phenyl)methyl)-butanamideGamma hydroxybutyric acid analogueUNII-U5CLZ223FHUNII-U-5CLZ223FHUNII-U 5CLZ223FH202402-01-5