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gevokizumab + cabozantinib
- Development stage
- Phase 1
- Lead developer
- Exelixis
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
**Gevokizumab + cabozantinib** is an investigational combination therapy combining gevokizumab, a recombinant humanized monoclonal antibody targeting interleukin-1 beta (IL-1β), with cabozantinib, a small molecule multi-tyrosine kinase inhibitor. Gevokizumab binds to and neutralizes IL-1β, mitigating pro-inflammatory pathways and potentially modulating the tumor immune microenvironment. Cabozantinib inhibits various receptor tyrosine kinases, including VEGFR-1, -2, and -3, MET, AXL, RET, KIT, FLT3, TIE2, and others, blocking tumor growth, metastasis, and angiogenesis. This combination is under early-stage clinical evaluation for solid tumors such as metastatic colorectal cancer, gastroesophageal cancer, and renal cell carcinoma, aiming to exploit synergistic anti-tumor and immunomodulatory effects[1][4][5][7].
- Other names
- gevokizumab + cabozantinib
02
Targets
AXL (AXL receptor tyrosine kinase)FLT3 (Fms related receptor tyrosine kinase 3)IL1B (Interleukin-1 beta)KIT (c-KIT proto-oncogene receptor tyrosine kinase)MET (Mesenchymal-epithelial transition factor receptor)RET (Rearranged during transfection receptor tyrosine kinase)ROS1 (Proto-oncogene tyrosine-protein kinase ROS)TEK (Tie2)NTRK2 (Tropomyosin-related kinase receptor type B)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)
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