Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
gGlu-HMRG
- Development stage
- Unknown
- Lead developer
- GORYO Chemical
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
GCP-001 (gGlu-HMRG) is an activatable fluorescent probe developed by GORYO Chemical for the intraoperative detection of cancer, specifically breast cancer. The probe is based on the hydroxymethyl rhodamine green (HMRG) fluorophore, which is initially in a non-fluorescent state due to quenching by a gamma-glutamyl group. Upon contact with the enzyme gamma-glutamyltransferase (GGT), which is frequently overexpressed on the surface of cancer cells, the gamma-glutamyl group is enzymatically cleaved, rapidly generating a strong fluorescent signal. This mechanism allows for real-time, high-contrast visualization of tumor margins and micro-metastases during surgery, aiding in complete resection. The agent has been evaluated in Phase 1 clinical trials at Kyushu University Beppu Hospital and is being developed in partnership with Solasia Pharma.
- Other names
- gGlu-HMRGgamma-glutamyl hydroxymethyl rhodamine greenGCP001GCP-001GCP 001
02
Targets
GGT2P (Gamma-glutamyltransferase 1)
Beyond the preview
Go deeper on gGlu-HMRG.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on gGlu-HMRG.