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GGN1231
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**GGN1231** is a novel *losartan-antioxidant hybrid compound* developed for potential therapeutic use in chronic renal failure and related cardiovascular conditions. Preclinical research indicates that GGN1231 combines the angiotensin II receptor antagonism of losartan with an antioxidant moiety, aiming to provide enhanced protective effects against cardiovascular damage, cardiac hypertrophy, and fibrosis in experimental models of chronic renal failure. In rat studies, GGN1231 showed preventive effects on vascular and cardiac damage, with a trend toward reduced mortality, though this reduction was not statistically significant[1][5].
- Other names
- GGN1231GGN-1231GGN 1231
02
Targets
AGTR1 (Angiotensin II Type-1 receptor)
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