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GHB04L1
- Development stage
- Phase 1
- Lead developer
- Baxter Healthcare Corporation
- Modality
- Live Attenuated Vaccines → Live Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intranasal
01
Overview
GHB04L1 is a live attenuated intranasal influenza A (H5N1) vaccine candidate based on a replication-deficient ΔNS1 mutant virus. The deletion of the non-structural protein 1 (NS1) gene renders the virus unable to replicate efficiently in normal hosts but allows for efficient replication in interferon-deficient cells used for production. Immunization with this ΔNS1 mutant induces an immune response without causing productive infection in humans. Preclinical studies demonstrated protection against wild-type H5N1 challenge in animal models. Clinical trials have evaluated its safety and immunogenicity as a prophylactic measure against pandemic influenza[2][5][1].
- Other names
- Influenza virus delta NS1 vaccineH5N1 influenza virus vaccineH-5N1 influenza virus vaccineH 5N1 influenza virus vaccineIntranasal H5N1 vaccine - Avir Green Hills BiotechnologyPandemic avian flu vaccine - Avir Green Hills Biotechnology
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