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GHB1589M
- Development stage
- Preclinical
- Lead developer
- Gatehouse Bio
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Inhalation
01
Overview
GHB1589M is a preclinical inhaled oligonucleotide therapeutic being developed by Gatehouse Bio for the treatment of idiopathic pulmonary fibrosis (IPF). Discovered using the company's AI-driven Code-Breaker™ platform, which identifies disease-driving small RNA (sRNA) isoforms, the drug is designed to target specific molecular mechanisms underlying lung fibrosis. By utilizing an inhaled delivery method, GHB1589M aims to provide direct therapeutic action within the lung tissue while minimizing systemic exposure.
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