Drug intelligence / Profile preview

giant salamander skin mucus extract hydrolyzate

Development stage
Preclinical
Modality
Hydrogel Systems → Drug Delivery Systems, Recombinant Proteins and Enzymes, Peptides
Administration
Oral, Topical
01

Overview

Giant salamander skin mucus extract hydrolyzate refers to the enzymatically processed bioactive peptides and proteins derived from the skin mucus of the Chinese giant salamander (Andrias davidianus). This substance is obtained through specific enzymatic hydrolysis methods that break down larger proteins into smaller peptides. Research indicates that these extracts possess a range of biological activities, including photoprotective effects against UVA-induced damage in cells[4], wound healing properties[6], anti-inflammatory activity via modulation of lincRNA-EPS/NF-κB signaling pathways[2], and potential antitumor effects by inhibiting cell migration, arresting cell cycle progression, and inducing apoptosis in cancer cells[1]. The primary mechanisms are attributed to small molecular weight collagen-derived peptides rich in hydrophobic amino acids. These extracts are being explored for use as medicinal functional foods, cosmeceuticals (skin care), and possibly as medical adhesives or wound dressings due to their strong tissue-sealing properties.

Other names
Andrias davidianus skin mucus enzymatic hydrolysateAD-APROChinese giant salamander skin mucus extract hydrolyzate
02

Targets

NF-κB

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