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GIC-102

Development stage
Phase 2
Lead developer
GI Cell
Modality
CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous
01

Overview

GIC-102 is an allogeneic, feeder-free natural killer (NK) cell therapy developed by GI Cell for the treatment of advanced solid tumors and hematologic malignancies, including non-Hodgkin lymphoma, metastatic colorectal cancer, and multiple myeloma. Derived from healthy donors and manufactured using a proprietary mass culture platform to ensure high purity and potency, GIC-102 is designed to maximize tumor-targeting function and cancer cell-killing efficiency. It is administered intravenously as an "off-the-shelf" product. Early clinical data indicate that GIC-102 monotherapy is well tolerated with no dose-limiting toxicities observed in phase 1 trials; it has shown promising efficacy signals such as complete response in non-Hodgkin lymphoma and stable disease in colorectal cancer patients. Combination studies with GI Innovation’s bi-specific Fc fusion protein (GI-101) are ongoing to further enhance anti-tumor activity[1][2][3][4][5][6].

Other names
T.O.P. NK

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