Drug intelligence / Profile preview

ginkgo biloba

Development stage
Unknown
Lead developer
Schwabe
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Ginkgo biloba is a botanical extract derived from the leaves of the *Ginkgo biloba* tree, one of the oldest living tree species. It is widely utilized as a herbal medicine or dietary supplement for the treatment of cognitive impairment, various forms of dementia (including Alzheimer's and vascular dementia), and peripheral vascular disorders such as intermittent claudication. The extract is typically standardized to contain specific concentrations of active constituents, primarily flavonoid glycosides (e.g., quercetin, kaempferol) and terpene lactones (ginkgolides A, B, C, and bilobalide). Its pharmacological profile includes potent antioxidant activity, antagonism of platelet-activating factor (PAF) receptors, and improvement of blood rheology through vasodilation and reduced blood viscosity. While marketed as a traditional medicine by companies like Ergon Pharmaceuticals in Bangladesh, it has been extensively studied in clinical trials globally and is regulated as a pharmaceutical product in several European countries.

Brand names
TeboninTanakanGinkgoldGinkopurGinkgo Biloba
Other names
Ginkgo biloba extractMaidenhair tree extractGBEFossil tree extract
02

Targets

PTAFR (Platelet-activating factor receptor)MAOB (Monoamine oxidase B)MAOA (Monoamine oxidase A)

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