Drug intelligence / Profile preview

ginkgo biloba + piracetam + vinpocetine

Development stage
Unknown
Lead developer
Ind Blues Pharma
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

**COG 3** is a fixed-dose combination cognitive enhancer developed and marketed by Ind Blues Pharma. It is formulated as an oral tablet containing three active ingredients: ginkgo biloba extract (60 mg), piracetam (800 mg), and vinpocetine (5 mg). This combination is primarily indicated for improving cognitive function, memory, and concentration in patients with neurodegenerative disorders such as dementia, Alzheimer's disease, and Parkinson's disease. Ginkgo biloba acts as an antioxidant and improves cerebral blood flow; piracetam is a nootropic that modulates cholinergic and glutamatergic systems to enhance neuroplasticity; and vinpocetine acts as a vasodilator and phosphodiesterase inhibitor to further enhance cerebral circulation and protect neurons from hypoxia.

Brand names
COG 3COG3COG-3Cog 3 TabletCog3 TabletCog-3 Tablet
Other names
ginkgo biloba + piracetam + vinpocetineginkgo biloba extract + piracetam + vinpocetine
02

Targets

AcetylcholinesteraseMAOA (Monoamine oxidase A)mAChR (Muscarinic acetylcholine receptors)NMDAR (Glutamate receptor ionotropic, NMDA)PDE1 (Phosphodiesterase 1)PTAFR (Platelet-activating factor receptor)NaV (Voltage-gated sodium channels)NEMO (NF-κB essential modulator)

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