Drug intelligence / Profile preview

ginkgo biloba + epimedium

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination product consisting of extracts from Ginkgo biloba leaves and Epimedium (commonly known as 淫羊藿 or "Horny Goat Weed"). The formulation typically uses standardized extracts—Ginkgo biloba extract is known for its vasodilatory and blood circulation-promoting effects, while Epimedium contains active compounds such as icariin that are traditionally used to tonify kidney yang and strengthen bones. The combination aims to synergistically enhance blood circulation, resolve stasis, supplement kidney function, and improve cognitive function. Preclinical studies suggest this combination may improve learning and memory in animal models of brain injury. It is primarily developed within the context of traditional Chinese medicine for indications such as Alzheimer's disease (senile dementia), cognitive impairment, osteoporosis, and other age-related conditions[1][5]. Mechanistically, Ginkgo acts via antioxidant activity and improvement of microcirculation; Epimedium exerts effects through modulation of inflammatory cytokines, reduction of oxidative stress responses, inhibition of amyloid-beta deposition in the brain (potentially relevant for Alzheimer's), androgenic activity (testosterone-like effect), and bone metabolism regulation[1][5].

Other names
银杏叶片 + 淫羊藿银杏叶提取物与淫羊藿总苷组合Ginkgo biloba extract + Epimedium total glycosides
02

Targets

PTAFR (Platelet-activating factor receptor)MMP1 (Matrix metalloproteinase-1)PDE5 (Phosphodiesterase 5A)

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